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Where does the pathway data come from?#

In HumanMine, we load pathway data from both Reactome and KEGG. However, note that the KEGG data has not been updated since May 2011 due to the current KEGG licensing requirements.

How do I find which pathways my gene or list of genes are involved in?#

Use the following template search:

Gene โ†’ Pathway

My gene is in pathway X; how I can find other genes involved in this pathway?#

Use the following template search:

Pathway โ†’ Genes

I am not sure of the exact name of the pathway that I am interested in; how I can find this?#

Under the Templates tab, start typing in the "Filter by description" box; matching pathways will automatically be shown. You can also use the "pathway" keyword to view all available pathways.

Can I visualize this pathway data in InterMine?#

We do have pathway visualizations within HumanMine at the bottom of every pathway-related template. In addition, provided links will enable you to also view the pathways in either Reactome or KEGG.

How do I find out if my genes or lists of genes have any pathways in common?#

The underlying data model makes it possible to construct queries that effectively compare two lists for a specified attribute. Such a query is available as a template for comparing the pathways for two genes or two sets of genes. For two genes, the query will return any pathways that are shared by the two genes. Similarly, if two lists are provided, any pathways shared between any two genes in the lists are returned. The template is:

Gene A โ†’ Pathways โ† Gene B

How do I find whether orthologues of my gene(s) share similar or have additional pathways?#

For a single gene, use the report page pathways viewer.

Each gene report page in HumanMine - and other MOD-InterMines - includes a table displaying pathways for the orthologues of the gene you are viewing. The table is created by searching the other InterMine databases for orthologous genes and the pathways they are involved in:

For a list of genes:

  1. Send your list of genes to the relevant organisms Mine:

see Open another organisms MOD-intermine via the orthologues of your list

  1. Once in the other Mine, search the templates for a search that will provide you with the pathway data for your genes.
  2. At present, we do not have a tool that will directly compare the pathways for your list of genes. However, if you download your pathway list (see Download a set of results) and upload it back into your original mine (see Upload a list), you can use the List Set operations: to carry out an intersection on the two pathway lists.